I can't call myself as a fan of Resident Evil, the games or the movies, but I have seen all of the movies and I think this was the worst one. It's not the end of the franchise either; I realize they never indicated Afterlife would conclude the "story", but this movie is just a placeholder. It's just a bunch of stuff that randomly happens (in 3D! Oooh!) after the last movie and before the next movie (and there will definitely be a Resident Evil 5). Ugh.
The Oatmeal just did a comic that has convinced me not to bother watching this movie. http://theoatmeal.com/comics/wwz I've listened to the audiobook several times and love it, so I'd recommend others to check that out.