I read somewhere that the writers originally intended for only two seasons of the show. The ratings for the show were so good, though, Fox told them to stretch it out to keep it going. If you go back and watch some of season 2 I think you can see writing that supports this as they started killing off characters willy-nilly.
The show isn't as strong now but it's still appointment TV for me. Great concept, pretty good execution throughout. I'll miss it. T-Bag (especially during the first three seasons) remains one of the best characters in TV history.
p.s. - What ever happened to that Prison Break "Cherry Hill" spinoff?? The one with the women's prison?
My 15 year old daughter who never saw the original movie (though you don't need to have watched it) convinced me to watch this new Fox show with her the last two weeks. I can't say I am enthralled with the show, but it's passable.