I play MMO's, so I got myself the Razor Naga. I love that all the buttons are on the side of the mouse, I hardly need to use the keyboard!
But....I've noticed I get hand cramps from using the buttons. Like bad hand cramps, along the where my thumb is (which is used for the side buttons). I don't know if it''s because of the layout of the buttons, ergonomics, or I'm spending too much time on the computer (I do IT so I'm already on the computer eight hours a day).
I never had this problem with the G5 I have.
After a (very) long hiatus, I have begun to write again. And this time, I'm not alone!
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Just look at your Task Manager, under the processes tab and sort it by the CPU column to see what's doing it. If you are using XP, it could be System Restore(a feature I find to be worthless but others like)