The key thing to understand is that Marvel is CHEAP thrifty and they would rather give opportunities to obviously talented but underused directors and actors than spend a fortune on someone that everyone knows is good.
Plus they have a pre-existing relationship with Joss on Runaways and Astonishing X-Men.
A lot of what Marvel is doing is convincing people to do their films for less (and signing them to multiple film deals) because being in a "cool" comic-book movie that makes a ton of dough will help their careers.
I love the show! I also started watching because of my love of Buffy/Angel. I think it's smart enough and tongue and cheek enough to not be associated with the CSI craze. I haven't watched last night yet....