A certain arachnid-based guy will dominate interest Wednesday. According to comicslist, there are lots of comics out coming out. I don't know what's interesting to anyone else, but I noticed Adventure Time #11 is at a jumping-on point and Spawn rolls on with #226, among many others.
The only good story arcs to come out of JMS' run were re-uniting MJ and Peter, and the big reveal where Aunt May discovers Peter is Spider-Man. The mythical spider stuff, organic webshooters, extra legs, and Gwen/Osborn twin stuff is garbage.