I don’t have any particular exotic hardware on my system, but Windows 7 still struggled to find drivers for basically everything. Screen resolution was limited to 640 x 480, and my external mouse didn’t work because apparently Windows 7 doesn’t have USB support. Bizarre. I’ll spare you the details of what I had to do to get the wireless working, but let’s just say it involved 27 hours of crying.
What I remember about ME is that it was a terrible OS. At work, we run XP on all our desktop clients. Its a much better OS, and support is readily available. If you can get it on a discount, I would go for it.