I don’t have any particular exotic hardware on my system, but Windows 7 still struggled to find drivers for basically everything. Screen resolution was limited to 640 x 480, and my external mouse didn’t work because apparently Windows 7 doesn’t have USB support. Bizarre. I’ll spare you the details of what I had to do to get the wireless working, but let’s just say it involved 27 hours of crying.
Also to clarify, are the USB ports built in to the motherboard or an add on card? If you plug the device in, then start the PC , does it go? Is it a brand name PC or whitebox? Is it likely to be under warranty?